Author
D. Bar-Sagi
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
Biology Disciplines
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2021-2022 · peak 3/yrCo-Author Collaboration Network
10 top collaborators · 14 mutual co-author links5 papers
Recent·Most cited
Chromosome 9p21.3 Coordinates Cell Intrinsic and Extrinsic Tumor Suppression
S. Lowe, F. M. Barriga, K. M. Tsanov, Y. J. Ho, N. Sohail, A. Zhang, T. Baslan, A. N. Wuest, I. Del Priore, B. Meskauskaite, G. Livshits, D. Alonso-Curbelo, J. Simon, A. Chaves-Perez, D. Bar-Sagi, , D. Pe'er
The paper investigates how 9p21.3 deletions in cancer disable both cell intrinsic and extrinsic tumor suppression by co-deleting CDKN2A/B and type I interferons, leading to immune evasion and metastasis.
bioRxiv · Aug 22, 2022 · PreprintCancer Biology
Pancreatic cancer ductal cell of origin drives CD73-dependent generation of immunosuppressive adenosine
K. Singh, E. Y. Faraoni, Y. Dai, V. Chandra, E. Vucic, T. Mills, M. Pruski, T. Clark, G. Van Buren, N. C. Thosani, J. S. Bynon, C. J. Wray, D. Bar-Sagi, K. L. Poulsen, L. A. Vornik, , J. Bailey Lundberg
This study identifies CD73 as a key driver of immunosuppression in pancreatic ductal adenocarcinoma, showing its role in adenosine generation and tumor progression.
bioRxiv · Nov 29, 2021 · PreprintCancer Biology
Integrated Systems-Analysis of the Human and Murine Pancreatic Cancer Glycomes Reveal a Tumor Promoting Role for ST6GAL1
E. Kurz, S. Chen, E. Vucic, G. Baptiste, C. Loomis, P. Agarwal, C. Hadju, D. Bar-Sagi, L. K. Mahal
The paper identifies ST6GAL1 as a promoter of pancreatic cancer using integrated glycomic and transcriptomic analysis across human and mouse models, showing delayed cancer formation and reduced fibrosis in a novel ST6GAL1 knockout model.
bioRxiv · Mar 10, 2021Cancer Biology
Adaptive stimulation of macropinocytosis overcomes aspartate limitation in cancer cells under hypoxia
J. Garcia-Bermudez, S. Prasad, L. Baudrier, M. A. Badgley, Y. Liu, K. La, M. Soula, R. T. Williams, N. Yamaguchi, R. F. Hwang, L. J. Taylor, E. De Stanchina, B. Rostandy, H. Alwaseem, H. Molina, , K. Birsoy
The paper identifies GOT2-catalyzed mitochondrial aspartate synthesis as essential for pancreatic tumor cell proliferation under hypoxia, but this dependency is bypassed by hypoxia-induced macropinocytosis.
bioRxiv · Feb 2, 2021Cancer Biology