Usp16 modulates Wnt signaling in primary tissues through Cdkn2a regulation
M. Adorno, B. Nicolis di Robilant, S. Sikandar, V. Haro Acosta, J. Antony, C. Heller, M. Clarke
This study shows Usp16 modulates Wnt signaling in tissues by regulating Cdkn2a, affecting stem cell expansion and regeneration, and identifies therapeutic implications for diseases like Down Syndrome.
bioRxiv · Jun 8, 2018Cell Biology