A computationally designed fluorescent biosensor for D-serine
V. Vongsouthi, J. H. Whitfield, P. Unichenko, J. A. Mitchell, B. Breithausen, O. Khersonsky, L. Kremers, H. Janovjak, H. Monai, H. Hirase, S. J. Fleishman, C. Henneberger, C. J. Jackson
The paper designs a fluorescent biosensor for D-serine by engineering an SBP with improved affinity, specificity, and thermostability, enabling its use in measuring D-serine concentrations in brain slices.
bioRxiv · Aug 18, 2020 · PreprintBiochemistry