Author

H. Hirase

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:fluorescence / live-cell microscopy· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Research Focus:host-pathogen & immune response· 1 Assay:imaging· 1 Organism:mouse· 1

Frequent Co-Authors

M. Nedergaard· 2 shared A. Aggarwal· 1 shared A. Asiminas· 1 shared A. G. Dietz· 1 shared A. Konno· 1 shared A. R. Kay· 1 shared B. Breithausen· 1 shared B. R. Taylor· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersPhysiology

M. Nedergaard

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Liver-secreted fluorescent blood plasma markers enable chronic imaging of microcirculation

X. Wang, C. Delle, A. Asiminas, S. Akther, M. Vittani, P. Brogger, P. Kusk, C. T. Vo, A. Konno, H. Hirai, M. Fukuda, P. Weikop, S. A. Goldman, M. Nedergaard, H. Hirase

This paper introduces a method to chronically image blood microcirculation using liver-secreted fluorescent proteins, enabling long-term observation of vascular functions in mice.

bioRxiv · Apr 8, 2022Physiology

A sensitive and specific genetically encodable biosensor for potassium ions

S.-Y. Wu, Y. Wen, N. B. C. Serre, C. C. H. Laursen, A. G. Dietz, B. R. Taylor, A. Aggarwal, V. Rancic, M. Becker, K. Ballanyi, K. Podgorski, H. Hirase, M. Nedergaard, M. Fendrych, M. J. Lemieux, , Y. Shen

The paper describes the development of a genetically encoded fluorescent K+ biosensor, GINKO2, optimized for sensitivity and specificity in vivo across multiple species.

bioRxiv · Oct 7, 2021 · PreprintBioengineering

A computationally designed fluorescent biosensor for D-serine

V. Vongsouthi, J. H. Whitfield, P. Unichenko, J. A. Mitchell, B. Breithausen, O. Khersonsky, L. Kremers, H. Janovjak, H. Monai, H. Hirase, S. J. Fleishman, C. Henneberger, C. J. Jackson

The paper designs a fluorescent biosensor for D-serine by engineering an SBP with improved affinity, specificity, and thermostability, enabling its use in measuring D-serine concentrations in brain slices.

bioRxiv · Aug 18, 2020 · PreprintBiochemistry