MDR1 Drug Efflux Pump Promotes Intrinsic and Acquired Resistance to PROTACs in Cancer Cells
A. M. Kurimchak, C. Herrera-Montavez, S. Montserrat-Sangra, D. Araiza-Olivera, J. Hu, J. Jin, J. S. Duncan
This study identifies MDR1 as a mediator of resistance to PROTACs in cancer cells and shows that combining MDR1 inhibitors with PROTACs enhances drug efficacy.
bioRxiv · Dec 2, 2021Cancer Biology