Chronic inflammation suppresses del(5q)-like MDS HSCs via p53
T. Muto, C. Walker, K. Choi, M. Niederkorn, C. Ishikawa, M. Varney, K. Hueneman, D. T. Starczynowski
This study shows chronic inflammation impairs del(5q)-like MDS HSPCs by activating p53, leading to reduced quiescence and disease severity, which may drive p53 mutations in myeloid malignancies.
bioRxiv · Jun 22, 2022 · PreprintCancer Biology