Author

C. J. B. daCosta

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

C. J. G. Tessier· 2 shared J. R. Emlaw· 2 shared R. M. Sturgeon· 2 shared F. J. Perez-Areales· 1 shared G. D. McCluskey· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

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2 shared papersBiophysics

C. J. G. Tessier

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2 papers

Recent·Most cited

BiophysicsbioRxivPreprintSep 13, 2022

Derepression masquerades as activation in a pentameric ligand-gated ion channel

C. J. G. Tessier, J. R. Emlaw, R. M. Sturgeon, C. J. B. daCosta

The paper shows that agonists relieve repression of intrinsic activity in a pentameric ligand-gated ion channel, suggesting agonist activation may be a form of derepression rather than direct activation.

DOI 10.1101/2022.09.13.507804

experimental assay

BiophysicsbioRxivJan 12, 2022

Ancestral acetylcholine receptor β-subunit forms homopentamers that prime before opening spontaneously

C. J. G. Tessier, R. M. Sturgeon, J. R. Emlaw…·C. J. B. daCosta

This study shows that an ancestral acetylcholine receptor β-subunit can form homopentamers that open spontaneously, independent of the modern heteropentameric structure.

DOI 10.7554/elife.76504

experimental assayprotein folding & dynamics