Derepression masquerades as activation in a pentameric ligand-gated ion channel
C. J. G. Tessier, J. R. Emlaw, R. M. Sturgeon, C. J. B. daCosta
The paper shows that agonists relieve repression of intrinsic activity in a pentameric ligand-gated ion channel, suggesting agonist activation may be a form of derepression rather than direct activation.
bioRxiv · Sep 13, 2022 · PreprintBiophysics