Pathogenic mitochondrial DNA mutations inhibit melanoma metastasis
S. D. Shelton, S. House, V. Ramesh, Z. Chen, T. Wei, X. Wang, C. B. Llamas, S. S. Venigalla, C. J. Menezes, Z. Zhao, J. G. Gill, R. J. DeBerardinis, S. J. Morrison, A. Tasdogan, P. Mishra
This study shows that pathogenic mtDNA mutations in melanoma cells reduce metastasis by limiting circulation entry, despite promoting tumor growth.
bioRxiv · Sep 1, 2023Cancer Biology