P. Mishra

Insulin-like Growth Factor 2 mRNA-binding protein 2 (IGF2BP2) Promotes Castration-Resistant Prostate Cancer Progression by Regulating AR-V7 mRNA Stability

This study shows IGF2BP2 promotes CRPC by stabilizing AR-V7 mRNA, making it a potential therapeutic target.

Preferred left-handed conformations of glycyls with pathogenic variants protect against aggregation

This study identifies that left-handed glycyl conformations protect against protein aggregation and enhance stability by disrupting beta-strand pairing.

Individual dietary amino acid restrictions induce distinct metabolic and chromatin states

The paper investigates how dietary restriction of specific essential amino acids affects metabolism and chromatin states in mice, finding distinct effects for methionine, leucine, and isoleucine.

Synthesis, Insertion and Characterization of SARS-CoV-2 Membrane Protein Within Lipid Bilayers

This study develops a method to express, purify, and insert SARS-CoV-2 M protein into lipid bilayers, characterizing its structural properties using AFM and Cryo-EM.

A Low-Cost Stage-Top Incubation Device For Human Cell Imaging Using Rapid Prototyping Methods

This paper describes a low-cost DIY stage-top incubation device for human cell imaging using 3D printing and SBCs, reducing costs by 100x compared to commercial alternatives.

Effect of ethanolic extract of Cyperus rotundus reduces the surgical induced secondary lymphedema and oxidative stress in adult mice tail

This study evaluates the effect of Cyperus rotundus root ethanolic extract on surgical-induced secondary lymphedema and oxidative stress in mice, finding reduced edema, inflammation, and histopathological damage.

Pathogenic mitochondrial DNA mutations inhibit melanoma metastasis

This study shows that pathogenic mtDNA mutations in melanoma cells reduce metastasis by limiting circulation entry, despite promoting tumor growth.

Adaptive Artificial Intelligence to Teach Interactive Molecular Dynamics in the Context of Human-Computer Interaction

This paper uses AI to analyze coordination dynamics in human-AI teams during interactive molecular dynamics tasks to foster discovery curiosity.

The evolution of sexual dimorphism in gene expression in response to a manipulation of mate competition

This study examines how mate competition affects sexual dimorphism in gene expression by evolving Drosophila melanogaster populations under different mating conditions.

Mitochondrial metabolism in primary and metastatic human kidney cancers

This study investigates mitochondrial metabolism in kidney cancers, finding that primary tumors have suppressed mitochondrial function while metastases show enhanced TCA cycle labeling.

Fusion of dysfunction muscle stem cells with myofibers induces sarcopenia in mice.

This study shows that muscle stem cell-myofiber fusion causes sarcopenia in mice, and blocking this fusion prevents muscle atrophy and extends lifespan.

LRBA balances antigen presentation and T-cell responses via autophagy through the binding to PIK3R4 and FYCO1

This study identifies LRBA's role in balancing antigen presentation and T-cell responses by interacting with PIK3R4 and FYCO1 to regulate autophagy.

A helminth mimic of TGF-β, TGM, enhances regenerative cutaneous wound healing and modulates immune cell recruitment and activation

This study shows that TGM, a helminth-derived TGF-β mimic, accelerates wound healing and reprograms macrophage activation through TGF-β receptor interactions.

Cis-regulatory variation in relation to sex and sexual dimorphism in Drosophila melanogaster

The paper investigates cis-regulatory variation in Drosophila melanogaster, finding widespread sex-specific effects and reversed allelic imbalance between sexes.

Mitochondrial-encoded complex I impairment induces a targetable dependency on aerobic fermentation in Hürthle cell carcinoma of the thyroid

This study shows that mitochondrial complex I defects in thyroid cancer drive reliance on aerobic fermentation, which can be targeted with lactate dehydrogenase inhibitors.

A complete allosteric map of a GTPase switch in its native network

The paper systematically identifies new allosteric regulatory sites in Gsp1/Ran by mutational scanning, revealing that many deleterious mutations affect function outside the active site through allosteric coupling.

Bronco T (Shirisadi kasaya), a polyherbal formulation ameliorates LPS induced septicemia in rats

Bronco T, a polyherbal formulation, improves survival and lung function in LPS-induced septicemia in rats, with effects comparable to pentoxifylline.

Cyperus rotundus root extract inhibits progress of lymphedema in mouse tail model

This study evaluates the effect of Cyperus rotundus root extract on lymphedema progression in a mouse tail model, finding reduced swelling and histological changes compared to the control group.

Differential requirements for mitochondrial electron transport chain components in the adult murine liver

This study investigates the tissue-specific roles of mitochondrial complex I and IV in adult mouse liver, finding that complex I loss is tolerated while complex IV dysfunction causes metabolic and functional impairments.

microRNA775 targets a β-(1,3)-galactosyltransferase to regulate growth and development in Arabidopsis thaliana

This study identifies miR775 as a regulator of growth and development in Arabidopsis thaliana by targeting a β-(1,3)-galactosyltransferase, affecting rosette size and responding to UV-B and hypoxia.

Abolished miR158 activity leads to 21-nucleotide tertiary phasiRNA biogenesis that targets NHX2 in Arabidopsis thaliana

The paper shows that reduced miR158 activity in Arabidopsis leads to 21-nucleotide tertiary phasiRNA generation targeting NHX2, affecting transpiration and stomatal conductance.

Adenosine metabolized from extracellular ATP promotes type 2 immunity through triggering A2BAR signaling on intestinal epithelial cells

The paper shows that adenosine from extracellular ATP via A2BAR on intestinal epithelial cells promotes type 2 immunity against helminth infection.

A Wnt5a-Cdc42 axis controls aging and rejuvenation of hair-follicle stem cells

This study identifies a Wnt5a-Cdc42 signaling axis that regulates hair-follicle stem cell aging and rejuvenation, showing that inhibiting Cdc42 activity restores canonical Wnt signaling and promotes hair regeneration.

Decision Support Systems based on Scientific Evidence: Bibliometric Networks of Invasive Lantana camara.

This paper introduces a bibliometric data analysis protocol using a Decision Support System to explore research themes, demonstrated with a case study on Lantana camara.

Isolation, identification and functional characterization of cultivable bacteria from Arabian Sea and Bay of Bengal water samples reveals high diversity

This study isolates and characterizes cultivable bacteria from Arabian Sea and Bay of Bengal water samples, revealing high diversity and functional roles in biogeochemical cycling.

Development of RNA-based assay for rapid detection of SARS-CoV-2 in clinical samples

This paper develops a rapid colorimetric assay for detecting SARS-CoV-2 RNA in clinical samples with high sensitivity and specificity.

Sperm-specific COX6B2 Enhances Oxidative Phosphorylation, Proliferation, and Survival in Lung Adenocarcinoma

The paper identifies COX6B2 as a sperm-specific gene that enhances oxidative phosphorylation, proliferation, and survival in lung adenocarcinoma by hijacking sperm motility metabolism.

Microbial diversity of the Arabian Sea in the Oxygen minimum zones by metagenomics approach

The paper uses metagenomics to analyze microbial diversity in oxygen minimum zones of the Arabian Sea, showing how environmental factors influence microbial community structure and function.

Flowering behaviour in Arabis alpina ensures the maintenance of a perennating dormant bud bank

This study shows that floral development during vernalization in Arabis alpina shapes the dormant bud zone by promoting synchronized growth and auxin levels after warming, while apical dominance and temperature regulate dormancy.

A strain of an emerging Indian pathotype of Xanthomonas oryzae pv. oryzae defeats the rice bacterial blight resistance gene xa13 without inducing a clade III SWEET gene and is nearly identical to a recent Thai isolate

The paper identifies an Xoo strain that bypasses xa13 resistance by not inducing clade III SWEET genes and is nearly identical to a Thai isolate.