R. J. DeBerardinis

A Lung Cancer Mouse Model Database

The paper establishes a database of lung cancer mouse models to improve data comparison and translational relevance by aligning mouse mutations with human lung cancer mutations.

RhoA activation promotes glucose uptake to elevate proliferation in MAPK inhibitor resistant melanoma cells.

This study identifies RhoA activation as a driver of glucose uptake and proliferation in MAPK inhibitor-resistant melanoma cells through ROCK-mediated IRS1 and PI3K pathway activation.

Pathogenic mitochondrial DNA mutations inhibit melanoma metastasis

This study shows that pathogenic mtDNA mutations in melanoma cells reduce metastasis by limiting circulation entry, despite promoting tumor growth.

Lysosomal mitochondrial interaction promotes tumor growth in squamous cell carcinoma of the head and neck

This study shows that lysosomal-mitochondrial interaction (LMI) promotes tumor growth in squamous cell carcinoma of the head and neck by enhancing mitochondrial complex I activity and lysosomal function.

Stable isotope tracing in human plasma-like medium reveals metabolic and immune modulation of the glioblastoma microenvironment

This paper develops an in vitro method using human plasma-like medium to study glioma metabolism and immune interactions, revealing microenvironment-dependent metabolic features and immune responses.

Electron transport inhibition increases cellular dependence on purine transport and salvage

This study shows that ETC inhibition in cancer cells increases reliance on purine salvage and transport, revealing a metabolic vulnerability in tumors with low oxidative metabolism.

FASN-deficiency induces a cytosol-to-mitochondria citrate flux to mitigate detachment-induced oxidative stress

This study shows that FASN-deficiency leads to a cytosol-to-mitochondria citrate flux via IDH1 and CTP, which helps cancer cells resist oxidative stress during detachment.

Mitochondrial metabolism in primary and metastatic human kidney cancers

This study investigates mitochondrial metabolism in kidney cancers, finding that primary tumors have suppressed mitochondrial function while metastases show enhanced TCA cycle labeling.

In-vivo characterization of glutamine metabolism identifies therapeutic targets in clear cell renal cell carcinoma

The paper identifies multiple glutamine metabolism pathways in ccRCC tumorgrafts and shows that targeting amidotransferase activity reduces tumor growth.

Adipocytes reprogram glucose metabolism in cancer cells promoting metastasis

This study shows adipocytes reprogram cancer cell glucose metabolism to promote metastasis by increasing lipid synthesis via HIF1 regulation.

The small cell lung cancer neuroendocrine transdifferentiation explorer

This study curates genes associated with NE transdifferentiation in SCLC and compares transcriptomic changes across multiple datasets to create a web tool for exploring NE transdifferentiation in SCLC and NBL.

Comprehensive isotopomer analysis of glutamate and aspartate in small tissue samples

This paper develops an MS method to analyze all 16 aspartate and 32 glutamate isotopomers with high sensitivity, enabling pathway discrimination and metabolic heterogeneity studies in human tumors.

The anti-angiogenic compound dimethyl fumarate inhibits the serine synthesis pathway and increases glycolysis in endothelial cells

This study shows dimethyl fumarate inhibits serine synthesis and increases glycolysis in endothelial cells, potentially explaining its anti-angiogenic effects.

De Novo Pyrimidine Synthesis is a Targetable Vulnerability in IDH Mutant Glioma

This study identifies de novo pyrimidine synthesis as a therapeutic target in IDH mutant gliomas, showing that DHODH inhibitors are effective in preclinical models.

G6PD deficiency sensitizes metastasizing melanoma cells to oxidative stress and glutaminolysis

This study shows that G6PD deficiency in melanoma cells increases oxidative stress and glutaminolysis, reducing metastasis by making cells more vulnerable to metabolic disruption.

Mitochondrial pyruvate supports lymphoma proliferation by fueling a non-canonical glutamine metabolism pathway

This study identifies a non-canonical glutamine metabolism pathway in DLBCLs where mitochondrial pyruvate supports glutaminolysis and proliferation, particularly in solid extracellular matrix environments.

Clinically-relevant T cell expansion protocols activate distinct cellular metabolic programs and phenotypes

The paper compares five T cell expansion protocols and finds they induce distinct metabolic programs and phenotypes, with some conditions impairing T cell function despite metabolic adaptation.

Differential requirements for mitochondrial electron transport chain components in the adult murine liver

This study investigates the tissue-specific roles of mitochondrial complex I and IV in adult mouse liver, finding that complex I loss is tolerated while complex IV dysfunction causes metabolic and functional impairments.

Relationship Between Neuroendocrine and Immune Gene Expression in Small Cell Lung Cancer

This study examines the relationship between neuroendocrine and immune gene expression in SCLC, finding that variant SCLC tumors regain immune gene expression and exhibit higher tumor-immune interactions.

1-Methylnicotinamide is an immune regulatory metabolite in human ovarian cancer

This study identifies 1-methylnicotinamide (MNA) as an immune regulatory metabolite in high-grade serous ovarian cancer, showing its role in modulating T cell function through non-cell autonomous mechanisms.

The hexosamine biosynthesis pathway is a targetable liability in lung cancers with concurrent KRAS and LKB1 mutations.

The paper identifies the hexosamine biosynthesis pathway as a metabolic vulnerability in KRAS/LKB1 mutant lung cancers and shows GFPT2 inhibition reduces tumor growth.

METABOLIC DIVERSITY IN HUMAN NON-SMALL CELL LUNG CANCER CELLS

The paper quantifies metabolic features in NSCLC cell lines to explore associations between metabolism and other cell-autonomous processes.