Author

C. J. Powell

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Biology Disciplines

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Biochemistry· 1

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Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

G. L. Dornan· 1 shared J. E. Burke· 1 shared J. T. Stariha· 1 shared M. J. Boulanger· 1 shared M. K. Rathinawamy· 1 shared

Activity by Year

2019-2019 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

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1 shared paperBiochemistry

G. L. Dornan

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1 paper

Recent·Most cited

Defining how oncogenic and developmental mutations of PIK3R1 alter the regulation of class IA phosphoinositide 3-kinases

G. L. Dornan, J. T. Stariha, M. K. Rathinawamy, C. J. Powell, M. J. Boulanger, J. E. Burke

This study investigates how mutations in PIK3R1 affect class IA PI3K regulation, finding that oncogenic mutations hyper-activate p110 while developmental mutations reduce RTK sensitivity.

bioRxiv · Jul 16, 2019Biochemistry