Author

J. T. Stariha

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:chromatin & epigenetic regulation· 2 Assay:structural biology· 2 Research Focus:cell signaling & trafficking· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

J. E. Burke· 4 shared C. K. Yip· 2 shared K. D. Fleming· 2 shared M. K. Rathinaswamy· 2 shared M. L. Jenkins· 2 shared U. Dalwadi· 2 shared B. R. S. Temple· 1 shared C. Adams· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersBiochemistry

J. E. Burke

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Author profile →

4 papers

Recent·Most cited

Molecular basis for differential activation of p101 and p84 complexes of PI3Kγ by Ras and GPCRs

M. K. Rathinaswamy, M. L. Jenkins, X. Zhang, J. T. Stariha, H. Ranga-Prasad, U. Dalwadi, K. D. Fleming, C. K. Yip, R. L. Williams, J. E. Burke

This study identifies molecular differences between p110γ-p84 and p110γ-p101 complexes that explain their differential activation by GPCRs and Ras.

bioRxiv · Jul 29, 2022Biochemistry

Dynamics of allosteric regulation of the phospholipase C-γ isozymes upon recruitment to membranes

E. Siraliev-Perez, J. Sondek, B. R. S. Temple, Q. Zhang, N. Hajicek, J. E. Burke, J. T. Stariha, R. M. Hoffmann, M. L. Jenkins

This study shows that PLC-gamma1 becomes active upon binding to FGFR1 kinase domain and membrane-bound PIP2, with an oncogenic mutation enhancing this activation.

bioRxiv · Feb 23, 2022Biochemistry

Structure of the phosphoinositide 3-kinase p110γ-p101 complex reveals molecular mechanism of GPCR activation

M. K. Rathinaswamy, U. Dalwadi, K. D. Fleming, C. Adams, J. T. Stariha, E. Pardon, M. Baek, O. Vadas, F. DiMaio, J. Steyaert, S. D. Hansen, C. K. Yip, J. E. Burke

The paper reports the cryo-EM structure of the p110γ-p101 complex, revealing how GPCR activation is mediated through interactions with Gβγ and identifying potential therapeutic targets.

bioRxiv · Jun 1, 2021Biochemistry

Defining how oncogenic and developmental mutations of PIK3R1 alter the regulation of class IA phosphoinositide 3-kinases

G. L. Dornan, J. T. Stariha, M. K. Rathinawamy, C. J. Powell, M. J. Boulanger, J. E. Burke

This study investigates how mutations in PIK3R1 affect class IA PI3K regulation, finding that oncogenic mutations hyper-activate p110 while developmental mutations reduce RTK sensitivity.

bioRxiv · Jul 16, 2019Biochemistry