Street RABV induces the cholinergic anti-inflammatory pathway in human monocyte-derived macrophages by binding to nAChr-a7, and upregulates the M2-c marker CD163
C. W. E. Embregts, L. Begeman, C. J. Voesenek, B. E. E. Martina, M. P. G. Koopmans, T. Kuiken, C. H. Geurtsvankessel
This paper shows that street RABV binds to nAChr-a7 on human macrophages, inducing the cholinergic anti-inflammatory pathway and promoting an anti-inflammatory M2-c phenotype.
bioRxiv · Jan 5, 2021Immunology