Author

C. W. E. Embregts

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:cell signaling & trafficking· 1 Assay:proteomics· 1

Frequent Co-Authors

D. van Riel· 3 shared F. M. S. de Vrij· 2 shared L. Bauer· 2 shared L. Leijten· 2 shared S. A. Kushner· 2 shared A. Bolleboom· 1 shared B. B. Oude Munnink· 1 shared B. E. E. Martina· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersMicrobiology

D. van Riel

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Dissecting MPXV neurotropism and host antiviral signaling using human stem cell-based models

L. Bauer, S. Giussani, N. Palazzi, E. Bot, E. Colombo, F. Zare, F. Pinci, L. Leijten, K. Lanko, F. F. W. Benavides, H. Smeenk, C. W. E. Embregts, J. K. H. Spoor, C. Dirven, Z. Gao, , O. Harschnitz

This study investigates MPXV neurotropism and antiviral signaling in CNS cells using human stem cell-derived models, finding that glial cells are more susceptible and exhibit reduced type I IFN responses.

bioRxiv · Aug 25, 2023 · PreprintMicrobiology

The potential role of human immune cells in the systemic dissemination of enterovirus-D68

B. M. Laksono, S. Sooksawasdi Na Ayudhya, M. Aguilar-Bretones, C. W. E. Embregts, G. P. van Nierop, D. van Riel

This study investigates how immune cells contribute to the systemic spread of EV-D68, showing that B cells and dendritic cells can be infected and facilitate virus dissemination.

bioRxiv · Dec 1, 2022 · PreprintMicrobiology

Replication kinetic, cell tropism and associated immune responses in SARS-CoV-2 and H5N1 virus infected human iPSC derived neural models

L. Bauer, B. Lendemeijer, L. Leijten, C. W. E. Embregts, B. Rockx, S. A. Kushner, F. M. S. de Vrij, D. van Riel

This study compares SARS-CoV-2 and H5N1 virus replication, cell tropism, and immune responses in human iPSC-derived neural cultures, finding sparse SARS-CoV-2 infection with immune activation versus efficient H5N1 replication.

bioRxiv · Mar 15, 2021Microbiology

Street RABV induces the cholinergic anti-inflammatory pathway in human monocyte-derived macrophages by binding to nAChr-a7, and upregulates the M2-c marker CD163

C. W. E. Embregts, L. Begeman, C. J. Voesenek, B. E. E. Martina, M. P. G. Koopmans, T. Kuiken, C. H. Geurtsvankessel

This paper shows that street RABV binds to nAChr-a7 on human macrophages, inducing the cholinergic anti-inflammatory pathway and promoting an anti-inflammatory M2-c phenotype.

bioRxiv · Jan 5, 2021Immunology