C. K. Bandi

Machine learning assisted ligand binding energy prediction for in silico generated glycosyl hydrolase enzyme combinatorial mutant library

The paper predicts binding energy for combinatorial mutants of an alpha-L-fucosidase using machine learning trained on docking data.

Carbohydrate binding domains facilitate efficient oligosaccharides synthesis by enhancing mutant catalytic domain transglycosylation activity

This study shows carbohydrate-binding domains enhance catalytic activity in chimeric CAZymes for efficient oligosaccharide synthesis.

Click-chemistry enabled directed evolution of glycosynthases for bespoke glycans synthesis

This paper develops a click-chemistry-based method for high-throughput screening of glycosynthase mutants to synthesize fucosylated oligosaccharides.