Genetic manipulation using hepatocyte-targeting adeno-associated viral vectors has minimal off-target effects.
C. Kiourtis, A. Wilczynska, C. Nixon, W. Clark, S. May, T. G. Bird
This study investigates the short-term off-target effects of AAV8 vectors in mice, finding minimal physiological and transcriptomic impacts with no evidence of liver injury.
bioRxiv · Feb 19, 2021 · PreprintCell Biology