Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
9 papers
Recent·Most cited
R. Wiesheu, S. C. Edwards, A. Hedley, M. Tosolini, M. G. F. Fares da Silva, N. Sumaria, Y. Optaczy, D. G. Hill, A. J. Hayes, J. Hay, A. Kilbey, A. M. Michie, G. Graham, A. Manoharan, C. Halsey, , S. B. Coffelt
The paper identifies immature and mature subsets of IFNγ-producing γδ T cells, showing IL-27 supports cytotoxic function in mature cells but not immature ones.
bioRxiv · Oct 26, 2023Immunology
J. Leslie, J. B. G. Mackey, T. Jamieson, E. Ramon-Gil, T. M. Drake, F. Fercoq, W. Clark, K. Gilroy, A. Hedley, C. Nixon, S. Luli, M. Laszczewska, R. Pinyol, R. Esteban-Fabro, C. E. Willoughby, , Carlin
This study shows that combining CXCR2 inhibition with anti-PD1 therapy enhances immunotherapy response in NASH-HCC by reprogramming tumor-associated neutrophils.
bioRxiv · Feb 24, 2022Cancer Biology
J. B. G. Mackey, A. J. McFarlane, T. Jamieson, R. Jackstadt, X. L. Raffo-Iraolagoitia, J. Secklehner, X. Cortes-Lavaud, F. Fercoq, W. Clarke, A. Hedley, K. Gilroy, S. Lilla, J. Vuononvirta, G. J. Graham, K. De Filippo, , L. M. Carlin
This study identifies Ly6G expression levels as a marker for neutrophil maturation stages and shows spleen-derived neutrophils mature faster with distinct transcriptional profiles.
bioRxiv · Jul 21, 2021 · PreprintImmunology
S. C. Edwards, A. Hedley, W. H. M. Hoevenaar, T. Glauner, R. Wiesheu, A. Kilbey, R. Shaw, K. Boufea, N. Batada, K. Blyth, C. Miller, K. Kirschner, S. B. Coffelt
This study identifies differential regulation of lung γδ T cell subsets by PD-1 and TIM-3 using single-cell RNA sequencing and flow cytometry.
bioRxiv · Jul 4, 2021Immunology
S. May, M. Mueller, C. R. Livingstone, G. Skalka, C. Nixon, A. Hedley, R. Shaw, W. Clark, T. M. Drake, C. Kiourtis, A. S. Rocha, O. J. Sansom, T. G. Bird
This study re-evaluates lineage tracing in Axin2CreERT2 mice and reports absence of pericentral hepatocyte expansion and altered Wnt pathway physiology.
bioRxiv · Dec 9, 2020 · PreprintCell Biology
R. S. Martinez, M. J. Salji, L. Rushworth, C. Ntala, G. Rodriguez Blanco, A. Hedley, W. Clark, P. Peixoto, E. Hervouet, E. Renaude, S. H. Kung, L. C. Galbraith, C. Nixon, S. Lilla, G. M. MacKay, , H. Y. Leung
This study identifies SLFN5 as an AR-regulated biomarker in CRPC that promotes tumour growth by regulating LAT1-mediated mTOR activation.
bioRxiv · Sep 17, 2020 · PreprintCancer Biology
R. Wiesheu, S. C. Edwards, A. Hedley, K. Kirschner, M. Tosolini, J.-J. Fournie, A. Kilbey, S.-J. Remak, C. Miller, K. Blyth, S. B. Coffelt
The paper identifies two subsets of CD27+ γδ T cells in mice, distinguished by Ly6C expression, with one subset showing memory-like properties and cancer-killing potential.
bioRxiv · Sep 8, 2020 · PreprintImmunology
E. J. Kay, K. Paterson, C. Riero Domingo, D. Sumpton, H. Daebritz, S. Tardito, C. Boldrini, J. R. Hernandez-Fernaud, D. Athineos, S. Dhayade, E. Stepanova, E. Gjerga, L. J. Neilson, S. Lilla, A. Hedley, , S. Zanivan
This study identifies PYCR1-dependent proline synthesis in cancer-associated fibroblasts as critical for collagen production and tumor progression, suggesting PYCR1 as a therapeutic target to inhibit pro-tumorigenic extracellular matrix deposition.
bioRxiv · May 30, 2020 · PreprintCancer Biology
B. Kruspig, T. Monteverde, S. Neidler, A. Hock, E. Kerr, C. Nixon, W. Clark, A. Hedley, C. Dick, K. Vousden, C. Martins, D. Murphy
This study shows that the ERBB network is required for KRAS-driven lung tumorigenesis and that inhibiting it enhances MEK inhibitor efficacy in treating such cancers.
bioRxiv · Apr 9, 2018Cancer Biology