Structure of the ceramide-bound SPOTS complex
J.-H. Schafer, C. Korner, B. M. Esch, S. Limar, K. Parey, S. Walter, D. Januliene, A. Moeller, F. Frohlich
The paper reports cryo-EM structures of the yeast SPT complex with Tsc3, Orm1, and Sac1, revealing ceramide-dependent inhibition and co-regulation of sphingolipid and sterol metabolism.
bioRxiv · Feb 3, 2023Biochemistry