Author

B. M. Esch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 4 Cell Biology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 6 Organism:yeast· 6 Research Focus:cell type annotation· 3 Assay:proteomics· 3 Assay:cryo-EM· 2 Research Focus:protein folding & dynamics· 2 Research Focus:protein structure prediction· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

S. Walter· 5 shared A. Moeller· 3 shared D. Januliene· 3 shared C. Körner· 2 shared F. Froehlich· 2 shared F. Frohlich· 2 shared F. Fröhlich· 2 shared J.-H. Schäfer· 2 shared

Activity by Year

2021-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

5 shared papersBiochemistry

S. Walter

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

The structure of the Orm2-containing serine palmitoyltransferase complex reveals distinct inhibitory potentials of yeast Orm proteins.

C. Körner, J.-H. Schäfer, B. M. Esch, K. Parey, S. Walter, D. Teis, D. Januliene, O. Schmidt, A. Moeller, F. Fröhlich

The paper determines the cryo-EM structure of the SPT-Orm2 complex and shows Orm2 has higher inhibitory potential than Orm1, despite similar structures.

bioRxiv · Jan 30, 2024Biochemistry

Structure of the yeast ceramide synthase

J.-H. Schäfer, L. Clausmeyer, C. Körner, B. M. Esch, V. N. Wolf, S. Walter, D. Januliene, A. Moeller, F. Fröhlich

This study determines the structure of the yeast ceramide synthase complex using cryo-EM, revealing its active state and inhibition mechanism by fumonisin B1.

bioRxiv · Oct 24, 2023Biochemistry

Ferroptosis-Protective Membrane Domains in Quiescence

A. H. Megarioti, A. Athanasopoulos, D. Koulouris, B. M. Esch, M. Makridakis, V. Lygirou, M. Samiotaki, J. Zoidakis, V. Sophianopoulou, B. Andre, F. Froehlich, C. Gournas

This study identifies FLPs as ferroptosis-protective membrane domains in yeast quiescence, preventing lipid peroxidation and promoting cell survival.

bioRxiv · Apr 27, 2023Cell Biology

Utilizing a nanobody recruitment approach for assessing serine palmitoyltransferase activity in ER sub-compartments of yeast.

B. M. Esch, S. Walter, O. Schmidt, F. Frohlich

The paper develops a nanobody recruitment system to measure SPT activity in yeast ER sub-compartments, identifying two distinct active SPT pools.

bioRxiv · Mar 29, 2023 · PreprintBiochemistry

Structure of the ceramide-bound SPOTS complex

J.-H. Schafer, C. Korner, B. M. Esch, S. Limar, K. Parey, S. Walter, D. Januliene, A. Moeller, F. Frohlich

The paper reports cryo-EM structures of the yeast SPT complex with Tsc3, Orm1, and Sac1, revealing ceramide-dependent inhibition and co-regulation of sphingolipid and sterol metabolism.

bioRxiv · Feb 3, 2023Biochemistry

A yeast lysosomal biogenesis map uncovers the cargo spectrum of lysosomal protein targeting pathways

S. Eising, B. M. Esch, M. Waelte, P. Vargas Duarte, S. Walter, C. Ungermann, M. Bohnert, F. Froehlich

The paper generates a lysosomal biogenesis map in yeast by combining proteomics and mutant analyses, revealing cargo-receptor relationships and novel CVT pathway cargo.

bioRxiv · Jul 24, 2021Cell Biology