Conserved prolines in the coiled coil-OB domain linkers of proteasomal ATPases facilitate eukaryotic proteasome base assembly
C. L. Cheng, M. K. Wong, Y. Li, M. Hochstrasser
This study identifies conserved prolines in Rpt subunits that facilitate proteasome base assembly by enabling ATPase heterodimerization, with mutations causing assembly defects and growth issues in yeast.
bioRxiv · Nov 13, 2020Biochemistry