M. Hochstrasser

A versatile new ubiquitin detection and purification tool derived from a bacterial deubiquitylase

The paper introduces OtUBD, a bacterial deubiquitylase-derived domain for ubiquitin detection and purification, showing its effectiveness in isolating ubiquitylated proteins from yeast and human samples.

The Wolbachia CinB Nuclease is Sufficient for Induction of Cytoplasmic Incompatibility

This paper shows that the Wolbachia CinB nuclease alone can induce cytoplasmic incompatibility in Drosophila males, with rescue by cognate CifA in females.

Selective Microautophagy of Proteasomes is Initiated by ESCRT-0 and Is Promoted by Proteasome Ubiquitylation

The paper identifies ESCRT-0 as a mediator of selective microautophagy of ubiquitylated proteasomes under low glucose conditions in yeast.

Conserved prolines in the coiled coil-OB domain linkers of proteasomal ATPases facilitate eukaryotic proteasome base assembly

This study identifies conserved prolines in Rpt subunits that facilitate proteasome base assembly by enabling ATPase heterodimerization, with mutations causing assembly defects and growth issues in yeast.

Crystal structure of a guanine nucleotide exchange factor encoded by the scrub typhus pathogen Orientia tsutsugamushi

The paper identifies a novel bacterial guanine nucleotide exchange factor (GEF) in Orientia tsutsugamushi that activates Rac1 and alters cell morphology.

AMPK regulates ESCRT-dependent microautophagy of proteasomes concomitant with proteasome storage granule assembly during glucose starvation

The paper shows AMPK and ESCRTs drive microautophagy of proteasomes during glucose starvation, leading to proteasome storage granule assembly and functional proteasome retention.