Author

C. L. Margerum

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Ghaffari· 1 shared A. W. B. Craig· 1 shared C. H. Graham· 1 shared D. R. Siemens· 1 shared D. Sanwalka· 1 shared E. Chan· 1 shared J.-F. Pare· 1 shared L. Minassian· 1 shared

Activity by Year

2023-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

A. Ghaffari

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1 paper

Recent·Most cited

Autophagy mediates cancer cell resistance to doxorubicin induced by the Programmed Death 1/Programmed Death Ligand 1 immune checkpoint axis

L. Minassian, D. Sanwalka, J.-F. Pare, S. Macdonald-Goodfellow, R. L. Sutherland, A. Ghaffari, C. L. Margerum, M. Koti, A. W. B. Craig, T. Cotechini, D. R. Siemens, E. Chan, C. H. Graham

This study shows that PD-1/PD-L1 signaling induces autophagy in cancer cells, contributing to drug resistance, and suggests combining PD-1/PD-L1 blockers with autophagy inhibitors could improve chemotherapy effectiveness.

bioRxiv · Jan 17, 2023 · PreprintCancer Biology