Author

D. R. Siemens

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1

Frequent Co-Authors

M. Koti· 4 shared D. M. Berman· 3 shared S. Chenard· 3 shared C. Jackson· 2 shared P. Yolmo· 2 shared S. Rahimi· 2 shared T. Jamaspishvilli· 2 shared A. Garven· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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4 shared papersCancer Biology

M. Koti

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Increased stromal densities of B cells, CD103+ cells, and CD163+ M2-like macrophages associate with poor clinical outcomes in BCG treated non-muscle invasive bladder cancer

B. Ravenscroft, P. Yolmo, S. Chenard, S. Rahimi, K. Pace, K. Sachdeva, T. Jamaspishvilli, H. Ghadei, A. Garven, K. Tyryshkin, D. M. Berman, C. Jackson, D. R. Siemens, M. Koti

This study identifies increased stromal densities of B cells, CD103+ cells, and CD163+ M2-like macrophages as predictors of poor clinical outcomes in BCG-treated NMIBC patients.

bioRxiv · Oct 19, 2023 · PreprintCancer Biology

Autophagy mediates cancer cell resistance to doxorubicin induced by the Programmed Death 1/Programmed Death Ligand 1 immune checkpoint axis

L. Minassian, D. Sanwalka, J.-F. Pare, S. Macdonald-Goodfellow, R. L. Sutherland, A. Ghaffari, C. L. Margerum, M. Koti, A. W. B. Craig, T. Cotechini, D. R. Siemens, E. Chan, C. H. Graham

This study shows that PD-1/PD-L1 signaling induces autophagy in cancer cells, contributing to drug resistance, and suggests combining PD-1/PD-L1 blockers with autophagy inhibitors could improve chemotherapy effectiveness.

bioRxiv · Jan 17, 2023 · PreprintCancer Biology

Carcinogen induced expansion of atypical B cells and pre-treatment tumor adjacent tertiary lymphoid structures associate with poor response to BCG in non-muscle invasive bladder cancer

P. Yolmo, S. Rahimi, S. Chenard, G. Conseil, D. Jenkins, I. Emon, J. Hamilton, M. Xu, M. Rangachari, E. Michaud, J. Mansure, D. M. Berman, D. R. Siemens, M. Koti

The paper shows that atypical B cells and pre-treatment tumor-associated tertiary lymphoid structures are linked to poor BCG response in NMIBC, with BBN-induced inflammation promoting ABCs in female mice.

bioRxiv · Dec 30, 2022 · PreprintCancer Biology

Sexual dimorphism in outcomes of non-muscle invasive bladder cancer: a role of CD163+ M2 macrophages, B cells and PD-L1 immune checkpoint.

S. Chenard, C. Jackson, T. Vidotto, L. Chen, C. Hardy, T. Jamaspishvilli, D. M. Berman, D. R. Siemens, M. Koti

This study identifies sexual dimorphism in NMIBC immune microenvironment, showing higher CD163+ macrophages and PD-L1 in female tumors, linked to worse recurrence-free survival.

bioRxiv · Jan 23, 2021Immunology