Molecular insights on CALX-CBD12 inter-domain dynamics from MD simulations, RDCs and SAXS
M. F. S. Degenhardt, P. A. M. Vitale, L. A. Abiko, M. Zacharias, M. Sattler, C. L. P. Oliveira, R. Kopke Salinas
The paper characterizes the conformational ensemble of CALX-CBD12 in the Apo state using MD simulations, NMR, and SAXS, showing preference for closed conformations and Ca2+-induced extension.
bioRxiv · Dec 18, 2020Biophysics