M. Sattler

Intrinsically disordered RNA-binding motifs cooperate to catalyze RNA folding and drive phase separation

This study identifies PUN motifs in yeast Loc1p that cooperate to catalyze RNA folding and drive phase separation, suggesting a role in RNA and DNA-related processes across species.

The Chloroplast RNA Binding Protein CP29A supports rbcL expression during cold acclimation

The prion-like domain of the chloroplast RNA binding protein CP29A is required for cold-induced phase separation next to nucleoids and supports RNA splicing and translation during cold acclimation

This study shows that the prion-like domain of CP29A enables temperature-dependent phase separation in Arabidopsis, supporting RNA splicing and translation during cold acclimation.

A novel PEX14/PEX5 interface links peroxisomal protein import and receptor recycling

This paper identifies a novel PEX14/PEX5 interface involved in peroxisomal protein import and receptor recycling through biochemical and structural analysis.

Intramolecular autoinhibition of human PEX13 modulates peroxisomal import

This study characterizes the PEX13 SH3 domain's interactions and autoinhibition mechanism, revealing its role in modulating peroxisomal import.

Structural basis for specific RNA recognition by the alternative splicing factor RBM5

This paper investigates how RBM5's RNA-binding domains recognize specific RNA motifs to regulate alternative splicing, revealing structural and cooperative mechanisms.

Reliability and accuracy of single-molecule FRET studies for characterization of structural dynamics and distances in proteins

This study evaluates the reliability and accuracy of single-molecule FRET for measuring protein structural dynamics and distances, finding high precision and accuracy with specific uncertainty limits.

Conformation and structural dynamics of the Xist lncRNA A-repeats

This study characterizes the conformational dynamics of Xist lncRNA A-repeats using an integrated approach of biochemical and biophysical techniques.

Npl3 functions in mRNP assembly by recruitment of mRNP components to the transcription site and their transfer onto the mRNA

The paper identifies Npl3's role in mRNP assembly by recruiting components to the transcription site and transferring them onto mRNA.

Despite the odds: formation of the SARS-CoV-2 methylation complex.

This study demonstrates that SARS-CoV-2 proteins nsp14, nsp10, and nsp16 form a heterotrimer complex, which modulates nsp14's exonuclease activity and protects viral RNA.

Modulation of pre-mRNA structure by hnRNP proteins regulates alternative splicing of MALT1

The paper shows hnRNP proteins modulate MALT1 pre-mRNA structure to regulate alternative splicing of exon7 by competing for RNA stem-loop binding.

Multifaceted N-degron recognition and ubiquitylation by GID/CTLH E3 ligases

The paper identifies novel N-terminal motifs recognized by Gid4 and Gid10 E3 ligases and shows how structural flexibility and substrate context influence ubiquitylation efficiency.

Inhibition of PLK1-dependent EBNA2 phosphorylation promotes lymphomagenesis in EBV-infected mice.

The paper shows that inhibiting PLK1-dependent EBNA2 phosphorylation enhances EBNA2 activity, promoting lymphoma development in EBV-infected mice.

Acriflavine, a clinically aproved drug, inhibits SARS-CoV-2 and other betacoronaviruses

This study identifies acriflavine as a potent inhibitor of SARS-CoV-2 and other betacoronaviruses, effective in cellular models, in vivo, and ex vivo.

Molecular insights on CALX-CBD12 inter-domain dynamics from MD simulations, RDCs and SAXS

The paper characterizes the conformational ensemble of CALX-CBD12 in the Apo state using MD simulations, NMR, and SAXS, showing preference for closed conformations and Ca2+-induced extension.

Structural evolution of the tissue-specific U2AF2 paralog and alternative splicing factor LS2

The paper determines the structure of the Drosophila LS2 protein's RRM domains and shows they interact with G quadruplex RNA motifs to regulate alternative splicing.

Competitive Microtubule Binding of PEX14 Coordinates Peroxisomal Protein Import and Motility

The paper shows PEX14 binds microtubules and competes with kinesin for binding sites, linking peroxisome motility and protein import.

DNA damage independent inhibition of NF-κB transcription by anthracyclines

This study shows anthracyclines inhibit NF-κB transcription without DNA damage, affecting inflammation independently of their DNA-damaging effects.

Molecular recognition and dynamics of linear poly-ubiquitins: integrating coarse-grain simulations and experiments

This paper combines coarse-grain simulations and experiments to study the conformational dynamics of linear poly-ubiquitin chains and their interaction with NEMO.

PINK1-dependent phosphorylation of Serine111 within the SF3 motif of Rab GTPases impairs effector interactions and LRRK2 mediated phosphorylation at Threonine72

This study shows that PINK1 phosphorylates Rab GTPases at Ser111, which inhibits LRRK2-mediated phosphorylation at Thr72, suggesting PINK1 activators could treat LRRK2-related Parkinson's.

Phenotypic Switching of Naïve T cells to Immune-suppressive Treg-like Cells by Mutant KRAS

The paper shows mutant KRAS induces T cells to become immune-suppressive Treg-like cells through exosomes, sera, or direct transfection, with single-cell sequencing identifying the interferon pathway as the mechanism.

Staufen2 mediated RNA recognition and localization requires combinatorial action of multiple domains

This study shows that dsRBDs 1-2 of mStau2 are essential for mRNA recognition and function, as demonstrated by rescue experiments in Drosophila oocytes.