Cell BiologybioRxiv
Genome-wide screens identify SEL1L as an intracellular rheostat controlling collagen turnover
M. J. Podolsky, B. Kheyfets, M. Pandey…·K. Atabai
The paper identifies SEL1L as a regulator of collagen turnover through a negative feedback loop, showing its role in limiting collagen accumulation in fibrotic lung disease.
DOI 10.1038/s41467-024-45817-8