LAMP2A regulates the loading of proteins into exosomes.
J. V. Ferreira, A. da Rosa Soares, J. S. Ramalho, C. M. Carvalho, M. H. Cardoso, P. Pintado, A. S. Carvalho, H. C. Beck, R. Matthiesen, M. Zuzarte, H. Girao, G. van Niel, P. Pereira
The paper identifies LAMP2A as a key regulator of protein loading into exosomes, independent of ESCRT machinery, and demonstrates its role in transporting hypoxia signals via exosomes.
bioRxiv · Jul 26, 2021Cell Biology