G. van Niel

Luminescence-based screening for extracellular vesicle release modulators reveals a role for PI4KIIIβ in exosome biogenesis upon lysosome inhibition

This study identifies PI4KIIIβ as a key mediator of exosome secretion upon lysosome inhibition using a luminescence-based screening approach.

Atheroprone shear stress stimulates noxious endothelial extracellular vesicle uptake by MCAM and PECAM-1 cell adhesion molecules

This study investigates how atheroprone and atheroprotective shear stress affects endothelial extracellular vesicle (EV) release and uptake, finding that LSS increases EV uptake through adhesion molecules like MCAM and PECAM-1.

Physical association of low density lipoprotein particles and extracellular vesicles unveiled by single particle analysis

This study investigates the physical association between low density lipoprotein particles and extracellular vesicles using single-particle analysis techniques and shows that LPPs can form complexes with EVs under physiological conditions.

Nuclear envelope disruption triggers hallmarks of aging in lung alveolar macrophages

This study shows that Lamin A/C protects lung alveolar macrophages from nuclear envelope rupture and aging-related DNA damage, linking NE disruption to genomic instability and senescence.

LAMP2A regulates the loading of proteins into exosomes.

The paper identifies LAMP2A as a key regulator of protein loading into exosomes, independent of ESCRT machinery, and demonstrates its role in transporting hypoxia signals via exosomes.

Origin of bidirectionality of cerebrospinal fluid flow and impact on long-range transport between brain and spinal cord

This study identifies the origin of bidirectional cerebrospinal fluid (CSF) flow in embryos and shows its role in long-range transport and embryonic growth.

Studying the fate of tumor extracellular vesicles at high spatio-temporal resolution using the zebrafish embryo

This study tracks tumor extracellular vesicles in zebrafish embryos using fluorescent probes, showing their uptake by endothelial cells and macrophages and their behavior in vivo.

Live tracking of inter-organ communication by endogenous exosomes in vivo

This paper develops a zebrafish model to track endogenous exosomes in vivo, revealing their release, uptake, and trophic role in inter-organ communication.