A subset of gut leukocytes have telomerase-dependent 'hyper-long' telomeres and require telomerase for function in zebrafish
P. S. Ellis, R. R. Martins, E. Thompson, A. Farhat, S. A. Renshaw, C. M. Henriques
This paper shows that telomerase-dependent 'hyper-long' telomeres in zebrafish gut macrophages and dendritic cells decline with age, leading to impaired immunity and increased gut permeability.
bioRxiv · Jan 31, 2022Cell Biology