Author

S. A. Renshaw

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 11 Cell Biology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:zebrafish· 14 Approach:experimental assay· 13 Research Focus:host-pathogen & immune response· 9 Research Focus:cell type annotation· 7 Research Focus:cell signaling & trafficking· 5 Assay:imaging· 4 Organism:human· 3 Assay:proteomics· 3

Frequent Co-Authors

C. A. Loynes· 4 shared T. K. Prajsnar· 4 shared N. V. Ogryzko· 3 shared P. M. Elks· 3 shared A. Bernut· 2 shared A. H. Meijer· 2 shared A. L. Robertson· 2 shared H. M. Isles· 2 shared

Activity by Year

2017-2022 · peak 6/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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4 shared papersImmunology

C. A. Loynes

Mutual co-authors in cluster

Author profile →

14 papers

Recent·Most cited

The EGFR/ErbB inhibitor neratinib modifies the neutrophil phosphoproteome and promotes apoptosis and clearance by airway macrophages

K. D. Herman, C. G. Wright, H. M. Marriott, S. C. McCaughran, M. Collins, S. A. Renshaw, L. R. Prince

This paper shows neratinib induces neutrophil apoptosis and enhances macrophage clearance in acute lung injury, supported by phosphoproteomics analysis.

bioRxiv · Apr 14, 2022Immunology

A subset of gut leukocytes have telomerase-dependent 'hyper-long' telomeres and require telomerase for function in zebrafish

P. S. Ellis, R. R. Martins, E. Thompson, A. Farhat, S. A. Renshaw, C. M. Henriques

This paper shows that telomerase-dependent 'hyper-long' telomeres in zebrafish gut macrophages and dendritic cells decline with age, leading to impaired immunity and increased gut permeability.

bioRxiv · Jan 31, 2022Cell Biology

Roscovitine exacerbates Mycobacterium abscessus infection by reducing NADPH oxidase-dependent neutrophil trafficking

V. Le Moigne, D. Rodriguez Rincon, S. Glatigny, C. Dupont, C. Langevin, A. Ait Ali Said, S. A. Renshaw, A. R. Floto, J.-L. Herrmann, A. Bernut

This study shows Roscovitine reduces neutrophil trafficking by inhibiting NADPH oxidase, worsening Mycobacterium abscessus infection in CF models.

bioRxiv · Jul 30, 2021 · PreprintMicrobiology

A zebrafish reporter line reveals immune and neuronal expression of endogenous retrovirus.

H. A. Rutherford, A. Clarke, E. V. Chambers, J. J. Petts, E. G. Carson, H. Isles, A. Duque-Jaramillo, S. A. Renshaw, J.-P. Levraud, N. Hamilton

This study creates a zebrafish ERV reporter line to identify tissues expressing endogenous retroviruses, revealing their presence in T cells and neurons.

bioRxiv · Jan 21, 2021Cell Biology

Neutrophils use selective autophagy receptor p62 to target Staphylococcus aureus for degradation in the zebrafish model

J. F. Gibson, T. K. Prajsnar, C. J. Hill, A. K. Tooke, J. J. Serba, R. D. Tonge, A. J. Grierson, P. W. Ingham, S. A. Renshaw, S. A. Johnston

This study shows p62 facilitates autophagy-mediated degradation of Staphylococcus aureus in zebrafish neutrophils.

bioRxiv · Feb 18, 2020Immunology

Human-specific staphylococcal virulence factors enhance pathogenicity in a humanised zebrafish C5a receptor model.

K. D. Buchan, M. van Gent, T. K. Prajsnar, N. V. Ogryzko, N. de Jong, J. Kolata, S. J. Foster, J. A. van Strijp, S. A. Renshaw

This study shows human-specific S. aureus toxins enhance pathogenicity in a humanised zebrafish model expressing the human C5a receptor.

bioRxiv · Feb 18, 2020Immunology

Deletion of cftr leads to an excessive neutrophilic response and defective tissue repair in a zebrafish model of sterile inflammation

A. Bernut, C. A. Loynes, R. A. Floto, S. A. Renshaw

This study shows that CFTR deletion in zebrafish causes excessive neutrophilic inflammation and impaired tissue repair, which can be mitigated by Tanshinone IIA.

bioRxiv · Nov 14, 2019Immunology

Evaluation of the anti-inflammatory effects of synthesised tanshinone I and isotanshinone I analogues in zebrafish

M. J. Foulkes, K. M. Henry, S. A. Renshaw, S. Jones

This study evaluates the anti-inflammatory effects of synthesised tanshinone and isotanshinone analogues in zebrafish, identifying compounds that accelerate inflammation resolution without affecting host defence.

bioRxiv · Sep 19, 2019Immunology

Endogenous pioneer neutrophils release NETs during the swarming response in zebrafish

H. M. Isles, C. A. Loynes, N. Hamilton, C. F. Muir, A. Kadochnikova, K. M. Henry, V. Kadirkamanathan, S. A. Renshaw, P. M. Elks

This study shows that endogenous neutrophils in zebrafish release NETs during the swarming response, revealing a potential role for NETosis in driving this process.

bioRxiv · Jun 5, 2019Immunology

The CXCL12/CXCR4 signalling axis retains neutrophils at inflammatory sites in zebrafish

H. M. Isles, K. D. Herman, A. L. Robertson, C. A. Loynes, L. R. Prince, P. M. Elks, S. A. Renshaw

This study shows that CXCL12/CXCR4 signaling retains neutrophils at inflammatory sites in zebrafish, and its inhibition accelerates inflammation resolution by promoting reverse migration.

bioRxiv · May 3, 2019Immunology

A transgenic zebrafish line for in vivo visualisation of neutrophil myeloperoxidase

K. D. Buchan, T. K. Prajsnar, N. V. Ogryzko, N. W. de Jong, M. van Gent, J. Kolata, S. J. Foster, J. A. G. A. Van Strijp, S. A. Renshaw

This paper introduces a transgenic zebrafish line expressing human MPO with a fluorescent tag to study neutrophil granule dynamics in vivo.

bioRxiv · Mar 20, 2019Immunology

The autophagic response to Staphylococcus aureus provides an intracellular niche in neutrophils

T. K. Prajsnar, J. J. Serba, B. M. Dekker, J. F. Gibson, S. Masud, A. Fleming, S. A. Johnston, S. A. Renshaw, A. H. Meijer

This study shows that S. aureus uses autophagy to create an intracellular niche in neutrophils, while p62-mediated autophagy protects the host.

bioRxiv · Mar 18, 2019 · PreprintImmunology

Hif-1alpha induced expression of Il-1beta protects against mycobacterial infection in zebrafish

N. V. Ogryzko, A. Lewis, H. L. Wilson, A. H. Meijer, S. A. Renshaw, P. M. Elks

The paper shows that Hif-1alpha increases Il-1beta expression in zebrafish macrophages, enhancing nitric oxide production and protecting against Mycobacterium marinum infection.

bioRxiv · Jul 30, 2018Immunology

PGE2 production at sites of tissue injury promotes an anti-inflammatory neutrophil phenotype and determines the outcome of inflammation resolution in vivo

C. A. Loynes, J. A. Lee, A. L. Robertson, M. J. G. Steel, F. Ellett, Y. Feng, B. D. Levy, M. K. Whyte, S. A. Renshaw

This study shows that PGE2 promotes neutrophil reverse migration and anti-inflammatory signaling, aiding inflammation resolution in a zebrafish model.

bioRxiv · Dec 20, 2017Immunology