Expression of the CIC-DUX4 fusion oncoprotein mimics human CIC-rearranged sarcoma in genetically engineered mouse models
P. G. Hendrickson, K. M. Oristian, M. R. Browne, L. Lou, Y. Ma, D. M. Cardona, C. M. Linardic, D. G. Kirsch
This study generates genetically engineered mouse models of CIC-DUX4 sarcoma that spontaneously develop tumors and express the fusion protein, validating CIC-DUX4 as a transcriptional activator.
bioRxiv · Sep 26, 2023 · PreprintCancer Biology