Cancer BiologybioRxivPreprint
Expression of the CIC-DUX4 fusion oncoprotein mimics human CIC-rearranged sarcoma in genetically engineered mouse models
P. G. Hendrickson, K. M. Oristian, M. R. Browne…·D. G. Kirsch
This study generates genetically engineered mouse models of CIC-DUX4 sarcoma that spontaneously develop tumors and express the fusion protein, validating CIC-DUX4 as a transcriptional activator.
DOI 10.1101/2023.09.26.559519