Control of G protein-coupled receptor function via membrane-interacting intrinsically disordered C-terminal domains
C. Mancinelli, D. C. Marx, A. J. Gonzalez-Hernandez, K. Huynh, L. Mancinelli, A. Arefin, G. Khelashvili, J. Levitz, D. Eliezer
This paper investigates how C-terminal domains of GPCRs interact with membranes to regulate receptor function, showing that these interactions influence transducer coupling and are modulated by phosphorylation and membrane composition.
bioRxiv · Aug 16, 2023 · PreprintBiophysics