K. Huynh

Signals beneath the ectoderm: Mesodermal FGF signaling keeps the dorsally closing epithelium in shape

The paper shows that mesodermal FGF signaling stabilizes the ectoderm during dorsal closure in Drosophila, revealing a reciprocal influence between mesoderm and ectoderm.

Beyond the Colony-Forming-Unit: Rapid Bacterial Evaluation in Osteomyelitis

This study demonstrates the discrepancy between colony-forming-unit and bacterial genome copy number in osteomyelitis and proposes an improved workflow for bacterial burden quantification in clinical specimens.

Multi-omics discovery of hallmark protein and lipid features of circulating small extracellular vesicles in humans

The paper identifies hallmark protein and lipid features of circulating extracellular vesicles in humans using multi-omics analysis and provides an open-source tool for further exploration.

Deep multi-omic profiling reveals extensive mitochondrial remodeling driven by glycemia in early diabetic kidney disease

This study shows that blood glucose levels directly affect mitochondrial function and metabolism in early diabetic kidney disease, with changes in proteome, metabolome, and lipidome.

Heat Inactivation of Aqueous Viable Norovirus and MS2 Bacteriophage

This study compares heat inactivation kinetics of viable human norovirus and MS2 bacteriophage using human intestinal enteroids, finding significant differences in decay rates and showing RNA titers do not reflect viable virus persistence.

Control of G protein-coupled receptor function via membrane-interacting intrinsically disordered C-terminal domains

This paper investigates how C-terminal domains of GPCRs interact with membranes to regulate receptor function, showing that these interactions influence transducer coupling and are modulated by phosphorylation and membrane composition.

Endocytosis is regulated through the pH-dependent phosphorylation of Rab GTPases by Parkinson's kinase LRRK2

This study shows that LRRK2 kinase phosphorylates Rab GTPases in response to pH changes, affecting endocytic vacuole formation and vesicular traffic.

An immune cell lipid atlas reveals the basis of susceptibility to ferroptosis

The paper characterizes immune cell lipidomes and shows how lipid composition influences susceptibility to ferroptosis.

Training-induced bioenergetic improvement in human skeletal muscle is associated with non-stoichiometric changes in the mitochondrial proteome without reorganization of respiratory chain content

The paper investigates training-induced mitochondrial adaptations in human skeletal muscle, finding non-stoichiometric changes in the proteome and challenging previous assumptions about bioenergetic improvements.

Revealing the high propensity of RNAs to non-specifically bind drug-like small molecules

This study examines the non-specific binding of three drug-like compounds to HIV-1 stem-loop RNAs, showing they inhibit RNA function and exhibit off-target interactions.

Inhibition and Crystal Structure of the Human DHTKD1-Thiamin Diphosphate Complex

This study identifies DHTKD1 inhibitors and reports its crystal structure with thiamin diphosphate, revealing how mutations affect its function and stability.