Author

A. J. Gonzalez-Hernandez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Assay:electrophysiology· 1 Assay:imaging· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

J. Levitz· 3 shared A. Arefin· 1 shared A. J. R. Plested· 1 shared A. Strauss· 1 shared B. Melancon· 1 shared B. Rivero-Perez· 1 shared C. Mancinelli· 1 shared D. Alvarez de la Rosa· 1 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersBiophysics

J. Levitz

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Deuteration provides a general strategy to enhance azobenzene-based photopharmacology

K. Rossmann, A. J. Gonzalez-Hernandez, R. Bhuyan, K. Boerjesson, J. Levitz, J. Broichhagen

This paper introduces deuterated azobenzene photoswitches to enhance photopharmacological molecules by improving light sensitivity, photoswitch efficiency, and kinetics.

bioRxiv · Nov 9, 2023 · PreprintBiochemistry

Control of G protein-coupled receptor function via membrane-interacting intrinsically disordered C-terminal domains

C. Mancinelli, D. C. Marx, A. J. Gonzalez-Hernandez, K. Huynh, L. Mancinelli, A. Arefin, G. Khelashvili, J. Levitz, D. Eliezer

This paper investigates how C-terminal domains of GPCRs interact with membranes to regulate receptor function, showing that these interactions influence transducer coupling and are modulated by phosphorylation and membrane composition.

bioRxiv · Aug 16, 2023 · PreprintBiophysics

Structural basis of allosteric modulation ofmetabotropic glutamate receptor activation and desensitization

A. Strauss, A. J. Gonzalez-Hernandez, J. Lee, N. Abreu, P. Selvakumar, L. Salas-Estrada, M. Kristt, D. Marx, K. Gilliland, B. Melancon, M. Filizola, J. Meyerson, J. Levitz

This study investigates how orthosteric and allosteric ligands affect mGluR activation and desensitization using electrophysiology, imaging, and cryo-EM structures.

bioRxiv · Aug 13, 2023 · PreprintBiophysics

State-dependent photocrosslinking unveiled the role of intersubunit interfaces on Ca2+ activating mechanisms of the BK channel

A. J. Gonzalez-Hernandez, B. Rivero-Perez, D. Bartolome-Martin, D. Alvarez de la Rosa, A. J. R. Plested, T. Giraldez

The paper uses photocrosslinking to identify intersubunit interfaces in BK channels critical for Ca2+ activation.

bioRxiv · Dec 15, 2022 · PreprintBiophysics