Mitochondrial oxidative stress drives IL-12/IL-18-induced IFN-gamma production by CD4+ T cells and is controlled by Fas
G. Rackov, P. T. Zaniani, S. C. del Pino, R. Shokri, M. A. Mon, C. Martinez-A, D. Balomenos
This study shows that mitochondrial oxidative stress (mROS) is essential for IL-12/IL-18-induced IFN-gamma production in memory-like CD4+ T cells and is regulated by Fas, independent of apoptosis.
bioRxiv · Jan 19, 2021 · PreprintImmunology