Crystallographic, kinetic, and calorimetric investigation of PKA interactions with L-type calcium channels and Rad GTPase
R. Yoo, O. Haji-Ghassemi, C. McFarlane, J. Xu, F. Van Petegem
This study identifies two tiers of PKA substrate sites in CaV1.2 and Rad, showing that Ser1981 and Ser25/Ser272 are preferentially phosphorylated, with structural insights into PKA's substrate recognition.
bioRxiv · Oct 24, 2023Biochemistry