R. Yoo

Target-agnostic identification of human antibodies to Plasmodium falciparum sexual forms reveals cross stage recognition of glutamate-rich repeats

The paper identifies human antibodies targeting Plasmodium falciparum sexual stages, revealing cross-stage recognition of glutamate-rich repeats through a novel method.

Crystallographic, kinetic, and calorimetric investigation of PKA interactions with L-type calcium channels and Rad GTPase

This study identifies two tiers of PKA substrate sites in CaV1.2 and Rad, showing that Ser1981 and Ser25/Ser272 are preferentially phosphorylated, with structural insights into PKA's substrate recognition.

NBI-921352, a First-in-Class, Na V 1.6 Selective, Sodium Channel Inhibitor That Prevents Seizures in Scn8a Gain-of- Function Mice, and Wild-Type Mice and Rats

This paper describes NBI-921352, a selective NaV1.6 inhibitor that prevents seizures in Scn8a gain-of-function mice and wild-type models, with better efficacy and tolerability than existing antiseizure drugs.

Synthesis of the novel transporter YdhC, is regulated by the YdhB transcription factor controlling adenosine and adenine uptake.

The paper shows that YdhB (AdnB) activates ydhC gene expression in E. coli, encoding an adenosine/adenine transporter, and demonstrates its role in nitrogen metabolism and growth under specific conditions.