Impact of MMP-2 and MMP-9 activation on wound healing, tumor growth and RACPP cleavage
L. G. Ellies, D. V. Hingorani, C. N. Lippert, J. L. Crisp, E. N. Savariar, J. P. C. Hasselmann, C. P. C. Kuo, Q. T. Nguyen, R. Y. Tsien, M. A. Whitney
This study investigates the role of MMP-2/-9 in wound healing and tumor progression using double knockout mice, finding that host macrophages, not tumor cells, are the main source of MMP-2/-9 activity in tumors.
PLOS ONE · Sep 24, 2018Peer-reviewedCancer Biology