CryoEM reveals unprecedented binding site for NaV1.7 inhibitors enabling rational design of potent hybrid inhibitors
M. Kschonsak, C. C. Jao, C. P. Arthur, A. L. Rohou, P. Bergeron, D. Ortwine, S. J. McKerrall, D. H. Hackos, L. Deng, J. Chen, D. S. Peter, M. Volgraf, M. Wright, J. Payandeh, C. Ciferri, J. C. Tellis
This study uses cryo-EM to reveal a new binding site for NaV1.7 inhibitors, enabling the design of hybrid inhibitors with improved selectivity and properties.
bioRxiv · Nov 10, 2022Bioengineering