Withaferin A inhibits LFA-1-stimulated ZAP70 activity and T-cell motility
F. Mobashar Hussain Urf Turabe, C. S. Chirumamilla, C. Perez-Novo, S. Kumar, S. K. Sze, W. V. Berghe, N. K. Verma
This study identifies that withaferin A inhibits T-cell motility by targeting ZAP70 and cytoskeletal pathways, offering potential for immune response modulation.
bioRxiv · Apr 25, 2021 · PreprintImmunology