S. K. Sze

Age-linked lung pathology is reduced by immunotherapeutic targeting of isoDGR protein damage

This study identifies isoDGR-damaged proteins as contributors to age-related lung pathology and shows that anti-isoDGR antibodies reduce lung damage in mice.

Ginsentide TP1 Protects Hypoxia-Induced Dysfunction and ER Stress-Linked Apoptosis

This study shows ginsentide TP1 protects human endothelial cells from hypoxia-induced dysfunction and ER stress-linked apoptosis by restoring NO signaling, reducing oxidative stress, and preventing endothelial activation.

Decoding the Cure-all Effects of Ginseng

This study identifies ginsentides as active compounds in ginseng that restore homeostasis under stress by interacting with multiple physiological systems.

Antibody targeting of aging damaged isoDGR-protein doubles lifespan in a mouse model of chronic inflammation

This paper shows that targeting aging-damaged isoDGR-proteins with antibodies extends lifespan in a mouse model of chronic inflammation.

Withaferin A inhibits LFA-1-stimulated ZAP70 activity and T-cell motility

This study identifies that withaferin A inhibits T-cell motility by targeting ZAP70 and cytoskeletal pathways, offering potential for immune response modulation.

Increased isoDGR motifs in plasma fibronectin are associated with atherosclerosis through facilitation of vascular fibrosis

This study shows that deamidated fibronectin with isoDGR motifs promotes vascular fibrosis and atherosclerosis by enhancing integrin signaling and leukocyte recruitment.

Plasmodium falciparum Replication factor C subunit 1 is involved in genotoxic stress response

This study investigates the role of PfRFC1 in the genotoxic stress response of Plasmodium falciparum, showing its involvement in DNA replication, repair, and programmed cell death.

ERO1α promotes hypoxic tumour progression and is associated with poor prognosis in pancreatic cancer

This study identifies ERO1α as a key driver of hypoxic pancreatic tumour progression and poor prognosis, supported by proteomic analysis and functional validation.