RNA sensing via LGP2 is essential for the induction of a type I IFN response in ADAR1 deficiency
J. E. Stok, T. Oosenbrug, L. R. ter Haar, D. Gravekamp, C. P. Bromley, S. Zelenay, C. Reis e Sousa, A. G. van der Veen
This study shows that LGP2 is essential for type I IFN induction in ADAR1-deficient cells, with implications for AGS and cancer therapy.
bioRxiv · Oct 27, 2021Immunology