The H2A.J histone variant contributes to Interferon-Stimulated Gene expression in senescence by its weak interaction with H1 and the derepression of repeated DNA sequences
Adèle Mangelinck, Clément Coudereau, Régis Courbeyrette, Khalid Ouararhni, Ali Hamiche, Christophe E. Redon, William M. Bonner, Erwin van Dijk, Céline Derbois, Robert Olaso, Jean‐François Deleuze, François Fenaille, C. Ruebe, Jean‐Yves Thuret, Carl Mann
This study identifies H2A.J's role in promoting ISG expression during senescence through its interaction with H1 and derepression of repeated DNA sequences.
bioRxiv · Oct 29, 2020 · PreprintGenetics