Carl Mann

The paper shows that fetal/neonatal fibroblasts show higher inflammatory gene expression than adult fibroblasts in IR-induced senescence due to differences in enhancer activity and FOXF1 levels.

The paper shows that loss of H2A.J impairs mitochondrial function in kidney tubular cells after radiation, leading to increased apoptosis and fibrosis.

This study shows that HP1 interacts with the RNA exosome, affecting RNA degradation and transcriptional programs in liver cells, with implications for cancer biology.

The paper shows that RNA accumulation, driven by reduced RNA turnover and oxidative stress, contributes to the inflammatory state of senescent cells.

This study identifies H2A.J's role in promoting ISG expression during senescence through its interaction with H1 and derepression of repeated DNA sequences.