Author

Adèle Mangelinck

Centre National de la Recherche ScientifiqueORCID 0009-0008-7454-8198Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Organism:human· 3 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Carl ManniD· 2 shared Ali HamicheiD· 1 shared C. Ruebe· 1 shared Céline Derbois· 1 shared Céline Lefèbvre· 1 shared Christian MuchardtiD· 1 shared Christophe E. RedoniD· 1 shared Christophe RacheziD· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersMolecular Biology

Carl MannORCID

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3 papers

Recent·Most cited

BioinformaticsPLoS ONEPeer-reviewedDec 27, 2024

The combined use of scRNA-seq and network propagation highlights key features of pan-cancer Tumor-Infiltrating T cells

Adèle Mangelinck, Elodie Molitor, Ibtissam Marchiq…·Céline Lefèbvre

The paper combines scRNA-seq and network propagation to refine gene signatures of TI-Tregs and Tex, revealing their biological processes and immunometabolic features.

2 citations

humanscRNA-seq

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Molecular BiologyLife Science AlliancePeer-reviewedJan 14, 2021

Reduced RNA turnover as a driver of cellular senescence

Nowsheen Mullani, Yevheniia Porozhan, Adèle Mangelinck…·Christian Muchardt

The paper shows that RNA accumulation, driven by reduced RNA turnover and oxidative stress, contributes to the inflammatory state of senescent cells.

32 citations

humanbulk RNA-seq

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GeneticsbioRxivPreprintOct 29, 2020

The H2A.J histone variant contributes to Interferon-Stimulated Gene expression in senescence by its weak interaction with H1 and the derepression of repeated DNA sequences

Adèle Mangelinck, Clément Coudereau, Régis Courbeyrette…·Carl Mann

This study identifies H2A.J's role in promoting ISG expression during senescence through its interaction with H1 and derepression of repeated DNA sequences.

16 citations

humanDNA methylation

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