Structural Basis for Stereoselective Dehydration and Hydrogen-Bonding Catalysis by the SAM-Dependent Pericyclase LepI
Y. Cai, Y. Hai, M. Ohashi, C. S. Jamieson, M. Garcia-Borras, K. N. Houk, J. Zhou, Y. Tang
This paper determines the structural basis for the stereoselective dehydration and hydrogen-bonding catalysis by LepI, revealing how it functions as a multifunctional pericyclase.
bioRxiv · Dec 10, 2018Biochemistry