Author

Y. Hai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cell Biology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell type annotation· 3 Organism:mouse· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Organism:fungi (other)· 2 Research Focus:protein folding & dynamics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

D. Chapman· 3 shared J. T. Field· 3 shared Y. Tang· 3 shared A. R. West· 2 shared J. W. Gordon· 2 shared M. D. Martens· 2 shared S. Ghavami· 2 shared W. Diehl-Jones· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersCell Biology

D. Chapman

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

The mitophagy receptor BNIP3L/Nix coordinates nuclear calcium signaling to modulate the muscle phenotype.

J. T. Field, D. Chapman, Y. Hai, S. Ghavami, A. R. West, B. Ozerklig, A. Saleem, J. Kline, A. A. Mendelson, J. Kindrachuk, B. Triggs-Raine, J. W. Gordon

This study shows Nix regulates muscle phenotype by coordinating mitophagy, ER-phagy, and nuclear calcium signaling, affecting insulin sensitivity and fiber-type composition.

bioRxiv · Mar 18, 2023 · PreprintCell Biology

Elucidating the molecular programming of a nonlinear nonribosomal peptide synthetase responsible for fungal siderophore biosynthesis.

M. Jenner, Y. Hai, H. H. Nguyen, M. Passmore, W. Skyrud, J. Kim, N. K. Garg, W. Zhang, R. R. Ogorzalek Loo, Y. Tang

This study characterizes the SidC NRPS involved in fungal siderophore biosynthesis, revealing non-canonical mechanisms in peptidyl siderophore assembly.

bioRxiv · Oct 10, 2022 · PreprintBiochemistry

Nix induced mitochondrial fission, mitophagy, and myocyte insulin resistance are abrogated by PKA phosphorylation.

S. C. da Silva Rosa, M. D. Martens, J. T. Field, L. Nguyen, S. Kereliuk, Y. Hai, D. Chapman, W. Diehl-Jones, M. Aliani, A. R. West, J. Thliveris, S. Ghavami, C. Rampitsch, V. W. Dolinsky, J. Gordon

The paper shows that Nix-induced mitochondrial fission, mitophagy, and insulin resistance in myocytes are reversed by PKA phosphorylation.

bioRxiv · Feb 20, 2020Cell Biology

A novel vaccine targeting the viral protease cleavage sites protects Mauritian cynomolgus macaques against vaginal SIVmac251 infection

H. Li, R. W. Omange, B. Liang, N. P. Toledo, Y. Hai, L. R. Liu, D. Schalk, J. C. Campo, T. G. Dacoba, A. B. Lambe, S.-Y. Lim, L. Li, M. A. Kashem, Y. Wan, J. F. Correia-Pinto, , M. Luo

A vaccine targeting viral protease cleavage sites provides >80% protection against vaginal SIVmac251 infection in macaques by inducing T cell responses and a protective immune environment.

bioRxiv · Nov 29, 2019 · PreprintMicrobiology

Structure-guided function discovery of an NRPS-like glycine betaine reductase for choline biosynthesis in fungi

Y. Hai, A. Huang, Y. Tang

The paper identifies an NRPS-like enzyme in fungi that catalyzes the reductive conversion of glycine betaine to choline, revealing its role in choline biosynthesis and homeostasis.

bioRxiv · Feb 24, 2019Biochemistry

Structural Basis for Stereoselective Dehydration and Hydrogen-Bonding Catalysis by the SAM-Dependent Pericyclase LepI

Y. Cai, Y. Hai, M. Ohashi, C. S. Jamieson, M. Garcia-Borras, K. N. Houk, J. Zhou, Y. Tang

This paper determines the structural basis for the stereoselective dehydration and hydrogen-bonding catalysis by LepI, revealing how it functions as a multifunctional pericyclase.

bioRxiv · Dec 10, 2018Biochemistry

Misoprostol regulates Bnip3 repression and alternative splicing to control cellular calcium homeostasis during hypoxic stress.

J. T. Field, M. D. Martens, W. Mughal, Y. Hai, D. Chapman, G. M. Hatch, T. L. Ivanco, W. Diehl-Jones, J. W. Gordon

This study shows misoprostol reduces Bnip3 expression and promotes alternative splicing to protect cells from hypoxia-induced damage by regulating calcium homeostasis.

bioRxiv · May 2, 2018Cell Biology