Author

C. S. Wylie

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biophysics· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Approach:statistical model· 1 Organism:yeast· 1

Frequent Co-Authors

D. M. Weinreich· 2 shared B. M. Rubenstein· 1 shared F. M. Ytreberg· 1 shared J. Huang· 1 shared J. S. Patel· 1 shared J. Yang· 1 shared M. T. Naik· 1 shared N. Naik· 1 shared

Activity by Year

2017-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiophysics

D. M. Weinreich

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Predicting the Viability of Beta-Lactamase: How Folding and Binding Free Energies Correlate with Beta-Lactamase Fitness

J. Yang, N. Naik, J. S. Patel, C. S. Wylie, W. Gu, J. Huang, F. M. Ytreberg, M. T. Naik, D. M. Weinreich, B. M. Rubenstein

This paper evaluates how well thermodynamic folding and binding free energies predict the fitness of beta-lactamase mutants using experimental data and computational models.

bioRxiv · Apr 15, 2020Biophysics

Sign of selection on mutation rate modifiers depends on population size

Y. Raynes, C. S. Wylie, P. D. Sniegowski, D. M. Weinreich

The paper shows that mutator alleles, which increase mutation rates, are favored by indirect selection in large populations but disfavored in smaller ones, demonstrating sign inversion in their selective effect.

bioRxiv · Jun 28, 2017Evolutionary Biology